Brief Report: Impaired CD4 T-Cell Response to Autophagy in Treated HIV-1-Infected Individuals

Brief Report: Impaired CD4 T-Cell Response to Autophagy in Treated HIV-1-Infected Individuals

Online publication: 14/02/2017 Printed publication: 1 February 2017 Journal: Journal of Acquired Immune Deficiency Syndrome

Abstract:

Autophagy restricts infection of CD4 T lymphocytes by HIV-1, but little is known about autophagy in treated HIV-1-infected individuals. We have analyzed the capability of CD4 T cells from aviremic-treated individuals to trigger autophagy and correlated this response with parameters known to be important for immunological recovery. Autophagy was significantly decreased in CD4 T cells from HIV-1-treated individuals compared with uninfected controls, and this defective autophagic response was more pronounced in individuals with poor CD4 T-cell recovery, suggesting a link between impaired autophagy in CD4 T cells and chronic immunological defects that remain in treated HIV infection.

Authors: Gómez-Mora E, Robert-Hebmann V, García E, Massanella M, Clotet B, Cabrera C, Blanco J, Biard-Piechaczyk M.

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Irsi Caixa

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