Pathogen Immunity, Signaling and Therapeutic Applications (PISTA)


Principal Investigator: Nuria Izquierdo-Useros


The world is becoming particularly vulnerable to emerging pathogens that thrive in new geographical areas due to climate warming and globalization trends. Although infectious diseases can be contained by host defenses, pathogens evolve to counteract human immunity. Our goal is to understand the underlying biology and basic aspects of human infection to develop new therapeutic strategies, and to steer the rational design of broad antimicrobial treatments to overcome multidrug resistance. 

To attain this aim, our group uses interdisciplinary cutting-edge technologies to perform multiple screenings integrating genomics, transcriptomics, high-throughput proteomics, super-resolution microscopy and functional inhibitory analyses, from the single-cell up to the tissue/organ level.

Keywords: Emerging pathogens, immune responses, host susceptibility, HIV-1 co-infections, host-directed therapies, personalized treatments
Principal Investigator

Nuria Izquierdo-Useros

Nuria Izquierdo-Useros is a biologist from Madrid who obtained her PhD from the Autonomous University of Barcelona (UAB) in 2009. Her research focuses on the interplay between antigen presenting cells and enveloped viruses, and includes studies of the...


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Irsi Caixa

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'La Caixa' Foundation Generalitat de Catalunya - Departament de Salut


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