Translational Research in Immunology and Ageing (TRIA)


Principal Investigator: Marta Massanella


Ageing is responsible for physiological dysfunctions in the different tissues, organs, and systems that leads to a decline in immune efficacy, resulting in increased vulnerability to infectious diseases, diminished responses to vaccination, and a major susceptibility to age-related inflammatory diseases. 

Our group focuses on translational studies to investigate the remodelling of the immune system during the process of ageing in the context of infectious diseases. Thus, our group focuses on two main lines of research: 

  • Inflammaging and immunosenescence during HIV infection. Despite the great improvement of welfare by ART, the prevalence of ageing-associated morbidities and age-related conditions is higher in the HIV-infected population. Our aim is to study this accelerated ageing and characterize the immune dysfunctions of ART-treated HIV-infected individuals to improve the quality of life of people living with HIV.
  • Immunopathogenesis of COVID-19 in elderly. We aim to characterise the immunopathogenic mechanisms associated with SARS-CoV-2 infection, in order to develop new therapeutic strategies to reduce mortality in the population group with the highest risk, the elderly population. 

By working in close collaboration with the Infectious Disease unit of the Germans Trias i Pujol University Hospital, the ultimate goal is to better understand age-associated immune dysregulation and immunosenescence, in order to identify novel strategies for immune rejuvenation, effective vaccination response and successful treatments in the older individuals. 

Keywords: Aging, ART, elderly, HIV co-morbidities, immune activation, immune senescence, inflammation, immunoaging, CoV
Principal Investigator

Marta Massanella

Marta Massanella graduated in Biology at the University Pompeu Fabra (Barcelona) and completed her PhD in Biomedicine at IrsiCaixa under the supervision of Dr. Julià Blanco in 2012. During her PhD, she characterized the immunodiscordant response to ART in HIV-treated individuals...


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Irsi Caixa

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'La Caixa' Foundation Generalitat de Catalunya - Departament de Salut


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